Structural basis of the Norrin-Frizzled 4 interaction
نویسندگان
چکیده
منابع مشابه
Structural basis of Wnt recognition by Frizzled.
Wnts are lipid-modified morphogens that play critical roles in development principally through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 (XWnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain Wnt structure, not obviously related to known protein folds, resembling a "hand" with "thumb" and "index" fingers extend...
متن کاملStructure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding to the Frizzled 4 (Fz4) receptor. Here we report the crystal structure of Norrin, which reveals a unique dimeric structure with each monomer adopting a conserved cystine knot fold. Functional studies demo...
متن کاملNorrin Protected Blood–Brain Barrier Via Frizzled-4/β- Catenin Pathway After Subarachnoid Hemorrhage
The pathophysiology of subarachnoid hemorrhage (SAH) and other stroke events involve the cerebral vascular neural network, which includes arterial and venous systems as well as neuronal cells and other support cells and matrix. Within this vascular neural network, blood–brain barrier (BBB) damage contributes to brain edema after SAH. Therefore, to improve clinical outcomes of patients with SAH,...
متن کاملNorrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization
Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 coreceptor, or Norrin ligand cause retinal hypovascularization, but the mechanisms by which Norrin/Fz4/Lrp signaling controls vascular development have not been defined. Using mouse genetic and cell culture models, we show that loss of Fz4 signalin...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2015
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2015.92